艾塞那肽, 97%
| 【编号】：107854 【产品名称】：艾塞那肽, 97% 【规格】：0.5mg 【用途】：   艾塞那肽, 97%
Product Name： Exendin-4
CAS号：141758-74-9
分子式：C184H282N50O60S
分子量：4186.57
介绍： Exendin-4是一种39个氨基酸的多肽
用途： Exendin-4能激活GLP-1受体，使该受体增加胰腺腺泡细胞(pancreatic acinar cells）的细胞内cAMP水平,但对VIP受体无效果。
贮存： 储存温度 -20°C
生化和生理学机理：
Exendin-4, a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. Exendin-4 stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1(glucagon-like peptide-1) receptor-dependent mechanism. Exendin-4, the long-acting GLP-1 receptor agonist, is an incretin mimetic approved for type 2 diabetes mellitus treatment. Studies also demonstrated its neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases.
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